Nature General Giant study finds untrustworthy trials pollute gold-standard medical reviews

Giant study finds untrustworthy trials pollute gold-standard medical reviews

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A microbiologists with the AEGIS Sciences Corporation processes Covid-19 and Monkeypox samples in a laboratory in Nashville, Tennessee.

Findings from clinical trials are summarized in Cochrane’s systematic reviews, which guide medical treatment.Credit: Nathan Posner/Anadolu Agency via Getty

A huge collaboration has confirmed growing concerns that fake or flawed research is polluting medical systematic reviews, which summarize evidence from multiple clinical trials and shape treatment guidelines worldwide. The study is part of an effort to address the problem by creating a short checklist that will help researchers to spot untrustworthy trials. Combined with automated integrity tools, this could help those conducting systematic reviews to filter out flawed work – in medicine and beyond.


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